The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance
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چکیده
منابع مشابه
Renal amyloidosis with a frame shift mutation in fibrinogen aalpha-chain gene producing a novel amyloid protein.
A French kindred with autosomal dominant hereditary renal amyloidosis was found to have a novel mutation in the fibrinogen Aalpha-chain gene. In this kindred, renal disease appeared early in life and led to terminal renal failure at an early age. Renal transplantation resulted in rapid destruction of the allograft by amyloid deposition within 2 years. Amyloid fibril protein isolated from a tran...
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The fibrinogen alphaC domain (Aalpha 220-610) is one of the earliest targets attacked by plasmin following fibrinolytic system activation. Monoclonal antibodies (MoAbs) to defined sequences within the alphaC domain provide the opportunity to explore the structure-function relationships involved in plasmin's interaction with its Aalpha chain substrate at greater resolution and can serve as reage...
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This report describes methods for the quantitative assay of human plasma profibrinolysin (plasminogen) and for the semi-quantitation of fibrinolytic factors in urine. The concentrations of plasma profibrinolysin, antifibrinolysin, fibrinogen and lytic factors in urine of patients with an active neoplasm and in pregnant women are compared with their concentrations in normal individuals. Although...
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ECENT YEARS have brought increased appreciation of the importance of the role of fibrinolysis in the regulation of normal hemostasis and in the production of abnormal bleeding. The mechanisms by which active fibrinolysis is induced are far from clear, but it does seem likely that it can be brought about by shock,1 severe emotional stress,2 injection of adrenalin,2 anoxia3 and liberation of acti...
متن کاملFibrinolytic Variables and Fibrinogen in Young and Old Healthy Adults
group by 22% (29.0±4.2 to 35.5±3.6 ml/kg/min, p<0.001). The young group had no significant changes in any of the measured variables, whereas the old group had a 39% increase in t-PA activity (0.82+0.47 to 1.14+0.42 IU/ml, p<0.03), a 141% increase in the percentage of t-PA in the active form (11.1+7.7 to 26.8+15.1%, p<0.01), a 58% decrease in PAI-1 activity (8.4+4.9 to 3.5±1.7 AU/mI,p<0.01), and...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2006
ISSN: 0007-1048,1365-2141
DOI: 10.1111/j.1365-2141.2006.06129.x